Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome

Olena Borodai; Tetyana Litovchenko

doi:doi:10.11648/j.ajpn.20221003.18

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Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome

Olena Borodai, Tetyana Litovchenko

Published in American Journal of Psychiatry and Neuroscience (Volume 10, Issue 3)

Received: 17 August 2022 Accepted: 2 September 2022 Published: 16 September 2022

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Abstract

Introduction: Injuries of peripheral nerves and plexuses usually cause serious impairment of the function of the affected limb. Peripheral nerve injuries not only affect the physical capabilities of the injured person due to the loss of motor or sensory function, but also have a significant impact on psychosocial aspects of life. Materials and Methods: The study included 93 men aged 21 to 59 years with neuropathies and plexopathies of traumatic and non-traumatic origin, which were divided into 3 groups. Neurological, electroneuromyographic, and ultrasound examinations were performed on the patients. The visual analog scale (VAS), the questionnaire DN4 (Douleur Neuropathique 4 Questions), and the questionnaire Pain Detect were used to determine the pain syndrome. The Hospital Anxiety and Depression Scale (HADS), the Center for Epidemiologic Studies Depression (CES-D) Scale, Spielberger State-Trait Anxiety Inventory (STAI) was used to assess and identify psycho-emotional disorders. Immunological examination was performed from 12 to 24 months from the onset of the disease. Results: The content of nerve growth factor (Beta-NGF) in patients of the III group at a statistically significant level depends on the presence of anxiety and depressive disorders in patients (Mann–Whitney U test, p=0.0231). Thus, in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is 404.9 [352.1; 1007] pg/ml, which is significantly higher than in patients without an anxiety and depressive disorder 58.3 [26; 322, 1] pg/ml. A correlation between the content of Beta-NGF and the visual analog scale (VAS) (R=0.88, p=0.00001) was revealed in patients with post-traumatic gunshot neuropathies and plexopathies accompanied by chronic neuropathic pain syndrome. Conclusion: Аccording to the obtained research data, signs of a subclinical and clinically expressed anxiety and depression can negatively affect the severity of the pain syndrome and its subjective assessment by the patient, thus reducing the effectiveness of drug correction of chronic neuropathic pain. It was found that in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is significantly higher (p=0.0231) than in patients without an anxiety and depressive disorder, which indicates the initiation of the homeostatic function of Beta-NGF in order to compensate for the existing pathophysiological changes.

Published in	American Journal of Psychiatry and Neuroscience (Volume 10, Issue 3)
DOI	10.11648/j.ajpn.20221003.18
Page(s)	145-153
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Post-Traumatic Neuropathies and Plexopathies, Chronic Neuropathic Pain Syndrome, Anxiety, Depression, Lymphocytotoxicity, Nerve Growth Factor

References

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Olena Borodai, Tetyana Litovchenko. (2022). Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome. American Journal of Psychiatry and Neuroscience, 10(3), 145-153. https://doi.org/10.11648/j.ajpn.20221003.18

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ACS Style

Olena Borodai; Tetyana Litovchenko. Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome. Am. J. Psychiatry Neurosci. 2022, 10(3), 145-153. doi: 10.11648/j.ajpn.20221003.18

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AMA Style

Olena Borodai, Tetyana Litovchenko. Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome. Am J Psychiatry Neurosci. 2022;10(3):145-153. doi: 10.11648/j.ajpn.20221003.18

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@article{10.11648/j.ajpn.20221003.18,
  author = {Olena Borodai and Tetyana Litovchenko},
  title = {Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {10},
  number = {3},
  pages = {145-153},
  doi = {10.11648/j.ajpn.20221003.18},
  url = {https://doi.org/10.11648/j.ajpn.20221003.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20221003.18},
  abstract = {Introduction: Injuries of peripheral nerves and plexuses usually cause serious impairment of the function of the affected limb. Peripheral nerve injuries not only affect the physical capabilities of the injured person due to the loss of motor or sensory function, but also have a significant impact on psychosocial aspects of life. Materials and Methods: The study included 93 men aged 21 to 59 years with neuropathies and plexopathies of traumatic and non-traumatic origin, which were divided into 3 groups. Neurological, electroneuromyographic, and ultrasound examinations were performed on the patients. The visual analog scale (VAS), the questionnaire DN4 (Douleur Neuropathique 4 Questions), and the questionnaire Pain Detect were used to determine the pain syndrome. The Hospital Anxiety and Depression Scale (HADS), the Center for Epidemiologic Studies Depression (CES-D) Scale, Spielberger State-Trait Anxiety Inventory (STAI) was used to assess and identify psycho-emotional disorders. Immunological examination was performed from 12 to 24 months from the onset of the disease. Results: The content of nerve growth factor (Beta-NGF) in patients of the III group at a statistically significant level depends on the presence of anxiety and depressive disorders in patients (Mann–Whitney U test, p=0.0231). Thus, in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is 404.9 [352.1; 1007] pg/ml, which is significantly higher than in patients without an anxiety and depressive disorder 58.3 [26; 322, 1] pg/ml. A correlation between the content of Beta-NGF and the visual analog scale (VAS) (R=0.88, p=0.00001) was revealed in patients with post-traumatic gunshot neuropathies and plexopathies accompanied by chronic neuropathic pain syndrome. Conclusion: Аccording to the obtained research data, signs of a subclinical and clinically expressed anxiety and depression can negatively affect the severity of the pain syndrome and its subjective assessment by the patient, thus reducing the effectiveness of drug correction of chronic neuropathic pain. It was found that in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is significantly higher (p=0.0231) than in patients without an anxiety and depressive disorder, which indicates the initiation of the homeostatic function of Beta-NGF in order to compensate for the existing pathophysiological changes.},
 year = {2022}
}

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TY  - JOUR
T1  - Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome
AU  - Olena Borodai
AU  - Tetyana Litovchenko
Y1  - 2022/09/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ajpn.20221003.18
DO  - 10.11648/j.ajpn.20221003.18
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 145
EP  - 153
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20221003.18
AB  - Introduction: Injuries of peripheral nerves and plexuses usually cause serious impairment of the function of the affected limb. Peripheral nerve injuries not only affect the physical capabilities of the injured person due to the loss of motor or sensory function, but also have a significant impact on psychosocial aspects of life. Materials and Methods: The study included 93 men aged 21 to 59 years with neuropathies and plexopathies of traumatic and non-traumatic origin, which were divided into 3 groups. Neurological, electroneuromyographic, and ultrasound examinations were performed on the patients. The visual analog scale (VAS), the questionnaire DN4 (Douleur Neuropathique 4 Questions), and the questionnaire Pain Detect were used to determine the pain syndrome. The Hospital Anxiety and Depression Scale (HADS), the Center for Epidemiologic Studies Depression (CES-D) Scale, Spielberger State-Trait Anxiety Inventory (STAI) was used to assess and identify psycho-emotional disorders. Immunological examination was performed from 12 to 24 months from the onset of the disease. Results: The content of nerve growth factor (Beta-NGF) in patients of the III group at a statistically significant level depends on the presence of anxiety and depressive disorders in patients (Mann–Whitney U test, p=0.0231). Thus, in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is 404.9 [352.1; 1007] pg/ml, which is significantly higher than in patients without an anxiety and depressive disorder 58.3 [26; 322, 1] pg/ml. A correlation between the content of Beta-NGF and the visual analog scale (VAS) (R=0.88, p=0.00001) was revealed in patients with post-traumatic gunshot neuropathies and plexopathies accompanied by chronic neuropathic pain syndrome. Conclusion: Аccording to the obtained research data, signs of a subclinical and clinically expressed anxiety and depression can negatively affect the severity of the pain syndrome and its subjective assessment by the patient, thus reducing the effectiveness of drug correction of chronic neuropathic pain. It was found that in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is significantly higher (p=0.0231) than in patients without an anxiety and depressive disorder, which indicates the initiation of the homeostatic function of Beta-NGF in order to compensate for the existing pathophysiological changes.
VL  - 10
IS  - 3
ER  -

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Author Information

Olena Borodai

Department of Neurology and Child Neurology, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
Tetyana Litovchenko

Department of Neurology and Child Neurology, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

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Olena Borodai, Tetyana Litovchenko. (2022). Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome. American Journal of Psychiatry and Neuroscience, 10(3), 145-153. https://doi.org/10.11648/j.ajpn.20221003.18

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ACS Style

Olena Borodai; Tetyana Litovchenko. Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome. Am. J. Psychiatry Neurosci. 2022, 10(3), 145-153. doi: 10.11648/j.ajpn.20221003.18

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AMA Style

Olena Borodai, Tetyana Litovchenko. Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome. Am J Psychiatry Neurosci. 2022;10(3):145-153. doi: 10.11648/j.ajpn.20221003.18

Copy | Download

@article{10.11648/j.ajpn.20221003.18,
  author = {Olena Borodai and Tetyana Litovchenko},
  title = {Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {10},
  number = {3},
  pages = {145-153},
  doi = {10.11648/j.ajpn.20221003.18},
  url = {https://doi.org/10.11648/j.ajpn.20221003.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20221003.18},
  abstract = {Introduction: Injuries of peripheral nerves and plexuses usually cause serious impairment of the function of the affected limb. Peripheral nerve injuries not only affect the physical capabilities of the injured person due to the loss of motor or sensory function, but also have a significant impact on psychosocial aspects of life. Materials and Methods: The study included 93 men aged 21 to 59 years with neuropathies and plexopathies of traumatic and non-traumatic origin, which were divided into 3 groups. Neurological, electroneuromyographic, and ultrasound examinations were performed on the patients. The visual analog scale (VAS), the questionnaire DN4 (Douleur Neuropathique 4 Questions), and the questionnaire Pain Detect were used to determine the pain syndrome. The Hospital Anxiety and Depression Scale (HADS), the Center for Epidemiologic Studies Depression (CES-D) Scale, Spielberger State-Trait Anxiety Inventory (STAI) was used to assess and identify psycho-emotional disorders. Immunological examination was performed from 12 to 24 months from the onset of the disease. Results: The content of nerve growth factor (Beta-NGF) in patients of the III group at a statistically significant level depends on the presence of anxiety and depressive disorders in patients (Mann–Whitney U test, p=0.0231). Thus, in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is 404.9 [352.1; 1007] pg/ml, which is significantly higher than in patients without an anxiety and depressive disorder 58.3 [26; 322, 1] pg/ml. A correlation between the content of Beta-NGF and the visual analog scale (VAS) (R=0.88, p=0.00001) was revealed in patients with post-traumatic gunshot neuropathies and plexopathies accompanied by chronic neuropathic pain syndrome. Conclusion: Аccording to the obtained research data, signs of a subclinical and clinically expressed anxiety and depression can negatively affect the severity of the pain syndrome and its subjective assessment by the patient, thus reducing the effectiveness of drug correction of chronic neuropathic pain. It was found that in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is significantly higher (p=0.0231) than in patients without an anxiety and depressive disorder, which indicates the initiation of the homeostatic function of Beta-NGF in order to compensate for the existing pathophysiological changes.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Anxiety-Depressive Disorders and Neurotrophic Control in Post-Traumatic Gunshot Neuropathies and Plexopathies Accompanied by Chronic Neuropathic Pain Syndrome
AU  - Olena Borodai
AU  - Tetyana Litovchenko
Y1  - 2022/09/16
PY  - 2022
N1  - https://doi.org/10.11648/j.ajpn.20221003.18
DO  - 10.11648/j.ajpn.20221003.18
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 145
EP  - 153
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20221003.18
AB  - Introduction: Injuries of peripheral nerves and plexuses usually cause serious impairment of the function of the affected limb. Peripheral nerve injuries not only affect the physical capabilities of the injured person due to the loss of motor or sensory function, but also have a significant impact on psychosocial aspects of life. Materials and Methods: The study included 93 men aged 21 to 59 years with neuropathies and plexopathies of traumatic and non-traumatic origin, which were divided into 3 groups. Neurological, electroneuromyographic, and ultrasound examinations were performed on the patients. The visual analog scale (VAS), the questionnaire DN4 (Douleur Neuropathique 4 Questions), and the questionnaire Pain Detect were used to determine the pain syndrome. The Hospital Anxiety and Depression Scale (HADS), the Center for Epidemiologic Studies Depression (CES-D) Scale, Spielberger State-Trait Anxiety Inventory (STAI) was used to assess and identify psycho-emotional disorders. Immunological examination was performed from 12 to 24 months from the onset of the disease. Results: The content of nerve growth factor (Beta-NGF) in patients of the III group at a statistically significant level depends on the presence of anxiety and depressive disorders in patients (Mann–Whitney U test, p=0.0231). Thus, in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is 404.9 [352.1; 1007] pg/ml, which is significantly higher than in patients without an anxiety and depressive disorder 58.3 [26; 322, 1] pg/ml. A correlation between the content of Beta-NGF and the visual analog scale (VAS) (R=0.88, p=0.00001) was revealed in patients with post-traumatic gunshot neuropathies and plexopathies accompanied by chronic neuropathic pain syndrome. Conclusion: Аccording to the obtained research data, signs of a subclinical and clinically expressed anxiety and depression can negatively affect the severity of the pain syndrome and its subjective assessment by the patient, thus reducing the effectiveness of drug correction of chronic neuropathic pain. It was found that in patients with post-traumatic gunshot neuropathies and plexopathies in the presence of an anxiety and depressive disorder, the level of Beta-NGF is significantly higher (p=0.0231) than in patients without an anxiety and depressive disorder, which indicates the initiation of the homeostatic function of Beta-NGF in order to compensate for the existing pathophysiological changes.
VL  - 10
IS  - 3
ER  -

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